Plant-derived alkaloids acting on dengue virus and their vectors: From chemistry to pharmacology

Chandan Sarkar; Cristina Quispe; Muhammad T. Islam; Sarmin Jamaddar; Muhammad Akram; Naveed Munior; Miquel Martorell; Manoj Kumar; Javad Sharifi-Rad; Natália Cruz-Martins

doi:10.2217/fmb-2021-0002

Plant-derived alkaloids acting on dengue virus and their vectors: From chemistry to pharmacology

Chandan Sarkar
, Cristina Quispe
, Muhammad T. Islam
, Sarmin Jamaddar
, Muhammad Akram
, Naveed Munior
, Miquel Martorell
, Manoj Kumar
, Javad Sharifi-Rad
, Natália Cruz-Martins

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Dengue is a mosquito-borne viral infection, with its prevention and control depending on effective vector control measures. At present, dengue virus (DENV) is an epidemic in more than 100 countries of Southeast Asia, Africa, Eastern Mediterranean, the Americas and the Western Pacific. Several alkaloids isolated from natural herbs can serve as a reservoir for antiDENV drug development. Traditionally, plant extracts rich in alkaloids are used for the treatment of fever and have also revealed antimicrobial activity against various pathogenic bacteria, fungi and virus. The present narrative review collates the literature-based scenario of alkaloids and derivatives acting on DENV. The mechanism of action of such alkaloids with antiDENV and vector activity is also discussed.

Original language	English
Pages (from-to)	143-155
Number of pages	13
Journal	Future Microbiology
Volume	17
Issue number	2
DOIs	https://doi.org/10.2217/fmb-2021-0002
State	Published - Jan 2022
Externally published	Yes

Keywords

Aedes
alkaloid
dengue
insecticidal
mosquito

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/fmb-2021-0002

Cite this

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title = "Plant-derived alkaloids acting on dengue virus and their vectors: From chemistry to pharmacology",

abstract = "Dengue is a mosquito-borne viral infection, with its prevention and control depending on effective vector control measures. At present, dengue virus (DENV) is an epidemic in more than 100 countries of Southeast Asia, Africa, Eastern Mediterranean, the Americas and the Western Pacific. Several alkaloids isolated from natural herbs can serve as a reservoir for antiDENV drug development. Traditionally, plant extracts rich in alkaloids are used for the treatment of fever and have also revealed antimicrobial activity against various pathogenic bacteria, fungi and virus. The present narrative review collates the literature-based scenario of alkaloids and derivatives acting on DENV. The mechanism of action of such alkaloids with antiDENV and vector activity is also discussed.",

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doi = "10.2217/fmb-2021-0002",

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TY - JOUR

T1 - Plant-derived alkaloids acting on dengue virus and their vectors

T2 - From chemistry to pharmacology

AU - Sarkar, Chandan

AU - Quispe, Cristina

AU - Islam, Muhammad T.

AU - Jamaddar, Sarmin

AU - Akram, Muhammad

AU - Munior, Naveed

AU - Martorell, Miquel

AU - Kumar, Manoj

AU - Sharifi-Rad, Javad

AU - Cruz-Martins, Natália

PY - 2022/1

Y1 - 2022/1

N2 - Dengue is a mosquito-borne viral infection, with its prevention and control depending on effective vector control measures. At present, dengue virus (DENV) is an epidemic in more than 100 countries of Southeast Asia, Africa, Eastern Mediterranean, the Americas and the Western Pacific. Several alkaloids isolated from natural herbs can serve as a reservoir for antiDENV drug development. Traditionally, plant extracts rich in alkaloids are used for the treatment of fever and have also revealed antimicrobial activity against various pathogenic bacteria, fungi and virus. The present narrative review collates the literature-based scenario of alkaloids and derivatives acting on DENV. The mechanism of action of such alkaloids with antiDENV and vector activity is also discussed.

AB - Dengue is a mosquito-borne viral infection, with its prevention and control depending on effective vector control measures. At present, dengue virus (DENV) is an epidemic in more than 100 countries of Southeast Asia, Africa, Eastern Mediterranean, the Americas and the Western Pacific. Several alkaloids isolated from natural herbs can serve as a reservoir for antiDENV drug development. Traditionally, plant extracts rich in alkaloids are used for the treatment of fever and have also revealed antimicrobial activity against various pathogenic bacteria, fungi and virus. The present narrative review collates the literature-based scenario of alkaloids and derivatives acting on DENV. The mechanism of action of such alkaloids with antiDENV and vector activity is also discussed.

KW - Aedes

KW - alkaloid

KW - dengue

KW - insecticidal

KW - mosquito

UR - https://www.scopus.com/pages/publications/85123391647

U2 - 10.2217/fmb-2021-0002

DO - 10.2217/fmb-2021-0002

M3 - Artículo de revisión

C2 - 34913374

AN - SCOPUS:85123391647

SN - 1746-0913

VL - 17

SP - 143

EP - 155

JO - Future Microbiology

JF - Future Microbiology

IS - 2

ER -

Plant-derived alkaloids acting on dengue virus and their vectors: From chemistry to pharmacology

Abstract

Keywords

UN SDGs

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