Phytotherapeutics in cancer invasion and metastasis

Bahare Salehi; Paolo Zucca; Mehdi Sharifi-Rad; Raffaele Pezzani; Sadegh Rajabi; William N. Setzer; Elena Maria Varoni; Marcello Iriti; Farzad Kobarfard; Javad Sharifi-Rad

doi:10.1002/ptr.6087

Phytotherapeutics in cancer invasion and metastasis

Bahare Salehi
, Paolo Zucca
, Mehdi Sharifi-Rad
, Raffaele Pezzani
, Sadegh Rajabi
, William N. Setzer
, Elena Maria Varoni
, Marcello Iriti
, Farzad Kobarfard
, Javad Sharifi-Rad

Shahid Beheshti University of Medical Sciences
University of Cagliari
Zabol University of Medical Sciences
University of Padua
Associazione Italiana per la Ricerca Oncologica di Base
University of Alabama in Huntsville
University of Milan
University of Winnipeg

Research output: Contribution to journal › Review article › peer-review

125 Scopus citations

Abstract

Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.

Original language	English
Pages (from-to)	1425-1449
Number of pages	25
Journal	Phytotherapy Research
Volume	32
Issue number	8
DOIs	https://doi.org/10.1002/ptr.6087
State	Published - Aug 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

adjuvant therapy
anticancer drugs
cancer chemoprevention
chemotherapy
phytochemicals
plant products

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10.1002/ptr.6087

Cite this

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title = "Phytotherapeutics in cancer invasion and metastasis",

abstract = "Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.",

keywords = "adjuvant therapy, anticancer drugs, cancer chemoprevention, chemotherapy, phytochemicals, plant products",

author = "Bahare Salehi and Paolo Zucca and Mehdi Sharifi-Rad and Raffaele Pezzani and Sadegh Rajabi and Setzer, \{William N.\} and Varoni, \{Elena Maria\} and Marcello Iriti and Farzad Kobarfard and Javad Sharifi-Rad",

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year = "2018",

month = aug,

doi = "10.1002/ptr.6087",

language = "Ingl{\'e}s",

volume = "32",

pages = "1425--1449",

journal = "Phytotherapy Research",

issn = "0951-418X",

publisher = "John Wiley and Sons Ltd",

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}

TY - JOUR

T1 - Phytotherapeutics in cancer invasion and metastasis

AU - Salehi, Bahare

AU - Zucca, Paolo

AU - Sharifi-Rad, Mehdi

AU - Pezzani, Raffaele

AU - Rajabi, Sadegh

AU - Setzer, William N.

AU - Varoni, Elena Maria

AU - Iriti, Marcello

AU - Kobarfard, Farzad

AU - Sharifi-Rad, Javad

PY - 2018/8

Y1 - 2018/8

N2 - Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.

AB - Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.

KW - adjuvant therapy

KW - anticancer drugs

KW - cancer chemoprevention

KW - chemotherapy

KW - phytochemicals

KW - plant products

UR - https://www.scopus.com/pages/publications/85047087260

U2 - 10.1002/ptr.6087

DO - 10.1002/ptr.6087

M3 - Artículo de revisión

C2 - 29672977

AN - SCOPUS:85047087260

SN - 0951-418X

VL - 32

SP - 1425

EP - 1449

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 8

ER -

Phytotherapeutics in cancer invasion and metastasis

Abstract

UN SDGs

Keywords

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