Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Javad Sharifi-Rad; Veronique Seidel; Michalak Izabela; Margalida Monserrat-Mequida; Antoni Sureda; Valeska Ormazabal; Felipe A. Zuniga; Shivaprasad Shetty Mangalpady; Raffaele Pezzani; Alibek Ydyrys; Gulmira Tussupbekova; Miquel Martorell; Daniela Calina; William C. Cho

doi:10.1186/s12964-023-01109-0

Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Javad Sharifi-Rad
, Veronique Seidel
, Michalak Izabela
, Margalida Monserrat-Mequida
, Antoni Sureda
, Valeska Ormazabal
, Felipe A. Zuniga
, Shivaprasad Shetty Mangalpady
, Raffaele Pezzani
, Alibek Ydyrys
, Gulmira Tussupbekova
, Miquel Martorell
, Daniela Calina
, William C. Cho

Universidad del Azuay
University of Strathclyde
Wrocław University of Science and Technology
University of the Balearic Islands
Fundació Institut d'Investigació Sanitària Illes Balears
Instituto de Salud Carlos III (ISCIII)
Universidad de Concepción
NMAM Institute of Technology
University of Padua
Associazione Italiana per la Ricerca Oncologica di Base
Al Farabi Kazakh National University
George Washington University
Craiova University of Medicine and Pharmacy
Queen Elizabeth Hospital Hong Kong

Research output: Contribution to journal › Review article › peer-review

98 Scopus citations

Abstract

Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. [MediaObject not available: see fulltext.]

Original language	English
Article number	89
Journal	Cell Communication and Signaling
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s12964-023-01109-0
State	Published - Dec 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis
Cancer
Cytotoxicity
Nrf2
Oxidative stress
Phenolic compounds

Access to Document

10.1186/s12964-023-01109-0

Cite this

Sharifi-Rad, J., Seidel, V., Izabela, M., Monserrat-Mequida, M., Sureda, A., Ormazabal, V., Zuniga, F. A., Mangalpady, S. S., Pezzani, R., Ydyrys, A., Tussupbekova, G., Martorell, M., Calina, D., & Cho, W. C. (2023). Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy. Cell Communication and Signaling, 21(1), Article 89. https://doi.org/10.1186/s12964-023-01109-0

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title = "Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy",

abstract = "Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. [MediaObject not available: see fulltext.]",

keywords = "Apoptosis, Cancer, Cytotoxicity, Nrf2, Oxidative stress, Phenolic compounds",

author = "Javad Sharifi-Rad and Veronique Seidel and Michalak Izabela and Margalida Monserrat-Mequida and Antoni Sureda and Valeska Ormazabal and Zuniga, \{Felipe A.\} and Mangalpady, \{Shivaprasad Shetty\} and Raffaele Pezzani and Alibek Ydyrys and Gulmira Tussupbekova and Miquel Martorell and Daniela Calina and Cho, \{William C.\}",

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doi = "10.1186/s12964-023-01109-0",

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Sharifi-Rad, J, Seidel, V, Izabela, M, Monserrat-Mequida, M, Sureda, A, Ormazabal, V, Zuniga, FA, Mangalpady, SS, Pezzani, R, Ydyrys, A, Tussupbekova, G, Martorell, M, Calina, D & Cho, WC 2023, 'Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy', Cell Communication and Signaling, vol. 21, no. 1, 89. https://doi.org/10.1186/s12964-023-01109-0

TY - JOUR

T1 - Phenolic compounds as Nrf2 inhibitors

T2 - potential applications in cancer therapy

AU - Sharifi-Rad, Javad

AU - Seidel, Veronique

AU - Izabela, Michalak

AU - Monserrat-Mequida, Margalida

AU - Sureda, Antoni

AU - Ormazabal, Valeska

AU - Zuniga, Felipe A.

AU - Mangalpady, Shivaprasad Shetty

AU - Pezzani, Raffaele

AU - Ydyrys, Alibek

AU - Tussupbekova, Gulmira

AU - Martorell, Miquel

AU - Calina, Daniela

AU - Cho, William C.

PY - 2023/12

Y1 - 2023/12

N2 - Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. [MediaObject not available: see fulltext.]

AB - Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. [MediaObject not available: see fulltext.]

KW - Apoptosis

KW - Cancer

KW - Cytotoxicity

KW - Nrf2

KW - Oxidative stress

KW - Phenolic compounds

UR - https://www.scopus.com/pages/publications/85157976201

U2 - 10.1186/s12964-023-01109-0

DO - 10.1186/s12964-023-01109-0

M3 - Artículo de revisión

C2 - 37127651

AN - SCOPUS:85157976201

SN - 1478-811X

VL - 21

JO - Cell Communication and Signaling

JF - Cell Communication and Signaling

IS - 1

M1 - 89

ER -

Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Abstract

UN SDGs

Keywords

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