Oridonin from Rabdosia rubescens: An emerging potential in cancer therapy – A comprehensive review

Muhammad Asif Ali; Noohela Khan; Ahmad Ali; Hira Akram; Noushaba Zafar; Kinza Imran; Tooba Khan; Khushbukhat Khan; Muhammad Armaghan; Marta Palma-Morales; Celia Rodríguez-Pérez; Angela Caunii; Monica Butnariu; Solomon Habtemariam; Javad Sharifi-Rad

doi:10.1002/fsn3.3986

Oridonin from Rabdosia rubescens: An emerging potential in cancer therapy – A comprehensive review

Muhammad Asif Ali
, Noohela Khan
, Ahmad Ali
, Hira Akram
, Noushaba Zafar
, Kinza Imran
, Tooba Khan
, Khushbukhat Khan
, Muhammad Armaghan
, Marta Palma-Morales
, Celia Rodríguez-Pérez
, Angela Caunii
, Monica Butnariu
, Solomon Habtemariam
, Javad Sharifi-Rad

UVAS
Rashid Latif Medical College
National University of Sciences and Technology Pakistan
Trials360
University of Granada
Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
Victor Babes University of Medicine and Pharmacy
Banat University of Agricultural Sciences and Veterinary Medicine
University of Greenwich
Universidad del Azuay

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Cancer incidences are rising each year. In 2020, approximately 20 million new cancer cases and 10 million cancer-related deaths were recorded. The World Health Organization (WHO) predicts that by 2024 the incidence of cancer will increase to 30.2 million individuals annually. Considering the invasive characteristics of its diagnostic procedures and therapeutic methods side effects, scientists are searching for different solutions, including using plant-derived bioactive compounds, that could reduce the probability of cancer occurrence and make its treatment more comfortable. In this regard, oridonin (ORI), an ent-kaurane diterpenoid, naturally found in the leaves of Rabdosia rubescens species, has been found to have antitumor, antiangiogenesis, antiasthmatic, antiinflammatory, and apoptosis induction properties. Extensive research has been performed on ORI to find various mechanisms involved in its anticancer activities. This review article provides an overview of ORI's effectiveness on murine and human cancer populations from 1976 to 2022 and provides insight into the future application of ORI in different cancer therapies.

Original language	English
Pages (from-to)	3046-3067
Number of pages	22
Journal	Food Science and Nutrition
Volume	12
Issue number	5
DOIs	https://doi.org/10.1002/fsn3.3986
State	Published - May 2024
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ORI
anticancer properties
cancer treatment
diterpenoid
natural compound

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10.1002/fsn3.3986

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Ali, M. A., Khan, N., Ali, A., Akram, H., Zafar, N., Imran, K., Khan, T., Khan, K., Armaghan, M., Palma-Morales, M., Rodríguez-Pérez, C., Caunii, A., Butnariu, M., Habtemariam, S., & Sharifi-Rad, J. (2024). Oridonin from Rabdosia rubescens: An emerging potential in cancer therapy – A comprehensive review. Food Science and Nutrition, 12(5), 3046-3067. https://doi.org/10.1002/fsn3.3986

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title = "Oridonin from Rabdosia rubescens: An emerging potential in cancer therapy {\textendash} A comprehensive review",

abstract = "Cancer incidences are rising each year. In 2020, approximately 20 million new cancer cases and 10 million cancer-related deaths were recorded. The World Health Organization (WHO) predicts that by 2024 the incidence of cancer will increase to 30.2 million individuals annually. Considering the invasive characteristics of its diagnostic procedures and therapeutic methods side effects, scientists are searching for different solutions, including using plant-derived bioactive compounds, that could reduce the probability of cancer occurrence and make its treatment more comfortable. In this regard, oridonin (ORI), an ent-kaurane diterpenoid, naturally found in the leaves of Rabdosia rubescens species, has been found to have antitumor, antiangiogenesis, antiasthmatic, antiinflammatory, and apoptosis induction properties. Extensive research has been performed on ORI to find various mechanisms involved in its anticancer activities. This review article provides an overview of ORI's effectiveness on murine and human cancer populations from 1976 to 2022 and provides insight into the future application of ORI in different cancer therapies.",

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month = may,

doi = "10.1002/fsn3.3986",

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Ali, MA, Khan, N, Ali, A, Akram, H, Zafar, N, Imran, K, Khan, T, Khan, K, Armaghan, M, Palma-Morales, M, Rodríguez-Pérez, C, Caunii, A, Butnariu, M, Habtemariam, S & Sharifi-Rad, J 2024, 'Oridonin from Rabdosia rubescens: An emerging potential in cancer therapy – A comprehensive review', Food Science and Nutrition, vol. 12, no. 5, pp. 3046-3067. https://doi.org/10.1002/fsn3.3986

TY - JOUR

T1 - Oridonin from Rabdosia rubescens

T2 - An emerging potential in cancer therapy – A comprehensive review

AU - Ali, Muhammad Asif

AU - Khan, Noohela

AU - Ali, Ahmad

AU - Akram, Hira

AU - Zafar, Noushaba

AU - Imran, Kinza

AU - Khan, Tooba

AU - Khan, Khushbukhat

AU - Armaghan, Muhammad

AU - Palma-Morales, Marta

AU - Rodríguez-Pérez, Celia

AU - Caunii, Angela

AU - Butnariu, Monica

AU - Habtemariam, Solomon

AU - Sharifi-Rad, Javad

PY - 2024/5

Y1 - 2024/5

N2 - Cancer incidences are rising each year. In 2020, approximately 20 million new cancer cases and 10 million cancer-related deaths were recorded. The World Health Organization (WHO) predicts that by 2024 the incidence of cancer will increase to 30.2 million individuals annually. Considering the invasive characteristics of its diagnostic procedures and therapeutic methods side effects, scientists are searching for different solutions, including using plant-derived bioactive compounds, that could reduce the probability of cancer occurrence and make its treatment more comfortable. In this regard, oridonin (ORI), an ent-kaurane diterpenoid, naturally found in the leaves of Rabdosia rubescens species, has been found to have antitumor, antiangiogenesis, antiasthmatic, antiinflammatory, and apoptosis induction properties. Extensive research has been performed on ORI to find various mechanisms involved in its anticancer activities. This review article provides an overview of ORI's effectiveness on murine and human cancer populations from 1976 to 2022 and provides insight into the future application of ORI in different cancer therapies.

AB - Cancer incidences are rising each year. In 2020, approximately 20 million new cancer cases and 10 million cancer-related deaths were recorded. The World Health Organization (WHO) predicts that by 2024 the incidence of cancer will increase to 30.2 million individuals annually. Considering the invasive characteristics of its diagnostic procedures and therapeutic methods side effects, scientists are searching for different solutions, including using plant-derived bioactive compounds, that could reduce the probability of cancer occurrence and make its treatment more comfortable. In this regard, oridonin (ORI), an ent-kaurane diterpenoid, naturally found in the leaves of Rabdosia rubescens species, has been found to have antitumor, antiangiogenesis, antiasthmatic, antiinflammatory, and apoptosis induction properties. Extensive research has been performed on ORI to find various mechanisms involved in its anticancer activities. This review article provides an overview of ORI's effectiveness on murine and human cancer populations from 1976 to 2022 and provides insight into the future application of ORI in different cancer therapies.

KW - ORI

KW - anticancer properties

KW - cancer treatment

KW - diterpenoid

KW - natural compound

UR - https://www.scopus.com/pages/publications/85184244019

U2 - 10.1002/fsn3.3986

DO - 10.1002/fsn3.3986

M3 - Artículo de revisión

AN - SCOPUS:85184244019

SN - 2048-7177

VL - 12

SP - 3046

EP - 3067

JO - Food Science and Nutrition

JF - Food Science and Nutrition

IS - 5

ER -

Oridonin from Rabdosia rubescens: An emerging potential in cancer therapy – A comprehensive review

Abstract

UN SDGs

Keywords

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