Medicinal and mechanistic overview of artemisinin in the treatment of human diseases

Anna Maria Posadino; Roberta Giordo; Gianfranco Pintus; Soheb Anwar Mohammed; Ilkay Erdogan Orhan; Patrick Valere Tsouh Fokou; Farukh Sharopov; Charles Oluwaseun Adetunji; Zehra Gulsunoglu-Konuskan; Alibek Ydyrys; Lorene Armstrong; Oksana Sytar; Miquel Martorell; Ahmad Faizal Abdull Razis; Babagana Modu; Daniela Calina; Solomon Habtemariam; Javad Sharifi-Rad; William C. Cho

doi:10.1016/j.biopha.2023.114866

Medicinal and mechanistic overview of artemisinin in the treatment of human diseases

Anna Maria Posadino
, Roberta Giordo
, Gianfranco Pintus
, Soheb Anwar Mohammed
, Ilkay Erdogan Orhan
, Patrick Valere Tsouh Fokou
, Farukh Sharopov
, Charles Oluwaseun Adetunji
, Zehra Gulsunoglu-Konuskan
, Alibek Ydyrys
, Lorene Armstrong
, Oksana Sytar
, Miquel Martorell
, Ahmad Faizal Abdull Razis
, Babagana Modu
, Daniela Calina
, Solomon Habtemariam
, Javad Sharifi-Rad
, William C. Cho

University of Sassari
University of Sharjah
University of Pittsburgh
Gazi University
Turkish Academy of Sciences (TÜBA)
University of Bamenda
Academy of Sciences of the Republic of Tadzhikistan
Edo State University Uzairue
Istanbul Aydin University
Al Farabi Kazakh National University
Universidade Estadual de Ponta Grossa
Universidade Federal do Paraná
Slovak University of Agriculture in Nitra
Universidad de Concepción
Universiti Putra Malaysia
University of Maiduguri
Craiova University of Medicine and Pharmacy
University of Greenwich
Universidad del Azuay
Queen Elizabeth Hospital Hong Kong

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua and has been traditionally used to treat conditions such as malaria, cancer, viral infections, bacterial infections, and some cardiovascular diseases, especially in Asia, North America, Europe and other parts of the world. This comprehensive review aims to update the biomedical potential of ART and its derivatives for treating human diseases highlighting its pharmacokinetic and pharmacological properties based on the results of experimental pharmacological studies in vitro and in vivo. Cellular and molecular mechanisms of action, tested doses and toxic effects of artemisinin were also described. The analysis of data based on an up-to-date literature search showed that ART and its derivatives display anticancer effects along with a wide range of pharmacological activities such as antibacterial, antiviral, antimalarial, antioxidant and cardioprotective effects. These compounds have great potential for discovering new drugs used as adjunctive therapies in cancer and various other diseases. Detailed translational and experimental studies are however needed to fully understand the pharmacological effects of these compounds.

Original language	English
Article number	114866
Journal	Biomedicine and Pharmacotherapy
Volume	163
DOIs	https://doi.org/10.1016/j.biopha.2023.114866
State	Published - Jul 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer
Antimicrobial
Antioxidant
Artemisinin
Pharmacological mechanisms
Safety profile

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10.1016/j.biopha.2023.114866

Cite this

Posadino, A. M., Giordo, R., Pintus, G., Mohammed, S. A., Orhan, I. E., Fokou, P. V. T., Sharopov, F., Adetunji, C. O., Gulsunoglu-Konuskan, Z., Ydyrys, A., Armstrong, L., Sytar, O., Martorell, M., Razis, A. F. A., Modu, B., Calina, D., Habtemariam, S., Sharifi-Rad, J., & Cho, W. C. (2023). Medicinal and mechanistic overview of artemisinin in the treatment of human diseases. Biomedicine and Pharmacotherapy, 163, Article 114866. https://doi.org/10.1016/j.biopha.2023.114866

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title = "Medicinal and mechanistic overview of artemisinin in the treatment of human diseases",

abstract = "Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua and has been traditionally used to treat conditions such as malaria, cancer, viral infections, bacterial infections, and some cardiovascular diseases, especially in Asia, North America, Europe and other parts of the world. This comprehensive review aims to update the biomedical potential of ART and its derivatives for treating human diseases highlighting its pharmacokinetic and pharmacological properties based on the results of experimental pharmacological studies in vitro and in vivo. Cellular and molecular mechanisms of action, tested doses and toxic effects of artemisinin were also described. The analysis of data based on an up-to-date literature search showed that ART and its derivatives display anticancer effects along with a wide range of pharmacological activities such as antibacterial, antiviral, antimalarial, antioxidant and cardioprotective effects. These compounds have great potential for discovering new drugs used as adjunctive therapies in cancer and various other diseases. Detailed translational and experimental studies are however needed to fully understand the pharmacological effects of these compounds.",

keywords = "Anticancer, Antimicrobial, Antioxidant, Artemisinin, Pharmacological mechanisms, Safety profile",

author = "Posadino, \{Anna Maria\} and Roberta Giordo and Gianfranco Pintus and Mohammed, \{Soheb Anwar\} and Orhan, \{Ilkay Erdogan\} and Fokou, \{Patrick Valere Tsouh\} and Farukh Sharopov and Adetunji, \{Charles Oluwaseun\} and Zehra Gulsunoglu-Konuskan and Alibek Ydyrys and Lorene Armstrong and Oksana Sytar and Miquel Martorell and Razis, \{Ahmad Faizal Abdull\} and Babagana Modu and Daniela Calina and Solomon Habtemariam and Javad Sharifi-Rad and Cho, \{William C.\}",

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year = "2023",

month = jul,

doi = "10.1016/j.biopha.2023.114866",

language = "Ingl{\'e}s",

volume = "163",

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Posadino, AM, Giordo, R, Pintus, G, Mohammed, SA, Orhan, IE, Fokou, PVT, Sharopov, F, Adetunji, CO, Gulsunoglu-Konuskan, Z, Ydyrys, A, Armstrong, L, Sytar, O, Martorell, M, Razis, AFA, Modu, B, Calina, D, Habtemariam, S, Sharifi-Rad, J & Cho, WC 2023, 'Medicinal and mechanistic overview of artemisinin in the treatment of human diseases', Biomedicine and Pharmacotherapy, vol. 163, 114866. https://doi.org/10.1016/j.biopha.2023.114866

TY - JOUR

T1 - Medicinal and mechanistic overview of artemisinin in the treatment of human diseases

AU - Posadino, Anna Maria

AU - Giordo, Roberta

AU - Pintus, Gianfranco

AU - Mohammed, Soheb Anwar

AU - Orhan, Ilkay Erdogan

AU - Fokou, Patrick Valere Tsouh

AU - Sharopov, Farukh

AU - Adetunji, Charles Oluwaseun

AU - Gulsunoglu-Konuskan, Zehra

AU - Ydyrys, Alibek

AU - Armstrong, Lorene

AU - Sytar, Oksana

AU - Martorell, Miquel

AU - Razis, Ahmad Faizal Abdull

AU - Modu, Babagana

AU - Calina, Daniela

AU - Habtemariam, Solomon

AU - Sharifi-Rad, Javad

AU - Cho, William C.

PY - 2023/7

Y1 - 2023/7

N2 - Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua and has been traditionally used to treat conditions such as malaria, cancer, viral infections, bacterial infections, and some cardiovascular diseases, especially in Asia, North America, Europe and other parts of the world. This comprehensive review aims to update the biomedical potential of ART and its derivatives for treating human diseases highlighting its pharmacokinetic and pharmacological properties based on the results of experimental pharmacological studies in vitro and in vivo. Cellular and molecular mechanisms of action, tested doses and toxic effects of artemisinin were also described. The analysis of data based on an up-to-date literature search showed that ART and its derivatives display anticancer effects along with a wide range of pharmacological activities such as antibacterial, antiviral, antimalarial, antioxidant and cardioprotective effects. These compounds have great potential for discovering new drugs used as adjunctive therapies in cancer and various other diseases. Detailed translational and experimental studies are however needed to fully understand the pharmacological effects of these compounds.

AB - Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua and has been traditionally used to treat conditions such as malaria, cancer, viral infections, bacterial infections, and some cardiovascular diseases, especially in Asia, North America, Europe and other parts of the world. This comprehensive review aims to update the biomedical potential of ART and its derivatives for treating human diseases highlighting its pharmacokinetic and pharmacological properties based on the results of experimental pharmacological studies in vitro and in vivo. Cellular and molecular mechanisms of action, tested doses and toxic effects of artemisinin were also described. The analysis of data based on an up-to-date literature search showed that ART and its derivatives display anticancer effects along with a wide range of pharmacological activities such as antibacterial, antiviral, antimalarial, antioxidant and cardioprotective effects. These compounds have great potential for discovering new drugs used as adjunctive therapies in cancer and various other diseases. Detailed translational and experimental studies are however needed to fully understand the pharmacological effects of these compounds.

KW - Anticancer

KW - Antimicrobial

KW - Antioxidant

KW - Artemisinin

KW - Pharmacological mechanisms

KW - Safety profile

UR - https://www.scopus.com/pages/publications/85159220191

U2 - 10.1016/j.biopha.2023.114866

DO - 10.1016/j.biopha.2023.114866

M3 - Artículo de revisión

C2 - 37182516

AN - SCOPUS:85159220191

SN - 0753-3322

VL - 163

JO - Biomedicine and Pharmacotherapy

JF - Biomedicine and Pharmacotherapy

M1 - 114866

ER -

Medicinal and mechanistic overview of artemisinin in the treatment of human diseases

Abstract

UN SDGs

Keywords

Access to Document

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