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Mechanistic Insight of Pharmacological Aspects of Violacein: Recent Trends and Advancements

  • Abhishek Chauhan
  • , Darin Mansor Mathkor
  • , Hemant Joshi
  • , Ritu Chauhan
  • , Ujjawal Sharma
  • , Vikas Sharma
  • , Manoj Kumar
  • , Reena V. Saini
  • , Adesh K. Saini
  • , Hardeep Singh Tuli
  • , Damandeep Kaur
  • , Shafiul Haque

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Since its discovery in the bacterium Chromobacterium violaceum, violacein—a striking purple pigment—has garnered significant interest due to its promising applications in the food and pharmaceutical industries. Violacein exhibits a range of pharmacological properties, including anti-inflammatory, anticancer, antibacterial, and antiparasitic effects, yet its complete molecular mechanisms are still being elucidated. Its mechanisms of action likely involve complex interactions with cellular receptors, signaling pathways, and specific molecular targets. Given violacein's unique properties and bioactive intermediates, future research holds substantial potential to advance its clinical and industrial applications. Upcoming studies will focus on deepening our understanding of violacein's molecular interactions, conducting clinical trials, and refining drug delivery systems to maximize its therapeutic value. Additionally, obtaining regulatory approval, conducting rigorous safety assessments, and developing efficient biosynthetic methods remain essential steps for violacein's successful integration into food biotechnology and medical applications.

Original languageEnglish
Article numbere70114
JournalJournal of Biochemical and Molecular Toxicology
Volume39
Issue number2
DOIs
StatePublished - Feb 2025

Keywords

  • Chromobacterium violaceum
  • biosynthesis pathways
  • chemoprevention
  • pharmacological mechanisms
  • safety evaluation

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