TY - JOUR
T1 - Luteolin
T2 - a flavonoid with a multifaceted anticancer potential
AU - Prasher, Parteek
AU - Sharma, Mousmee
AU - Singh, Sachin Kumar
AU - Gulati, Monica
AU - Chellappan, Dinesh Kumar
AU - Zacconi, Flavia
AU - De Rubis, Gabriele
AU - Gupta, Gaurav
AU - Sharifi-Rad, Javad
AU - Cho, William C.
AU - Dua, Kamal
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Therapeutic effect of phytochemicals has been emphasized in the traditional medicine owing to the presence of bioactive molecules, such as polyphenols. Luteolin is a flavone belonging to the flavonoid class of polyphenolic phytochemicals with healing effect on hypertension, inflammatory disorders, and cancer due to its action as pro-oxidants and antioxidants. The anticancer profile of luteolin is of interest due to the toxic effect of contemporary chemotherapy paradigm, leading to the pressing need for the development and identification of physiologically benevolent anticancer agents and molecules. Luteolin exerts anticancer activity by downregulation of key regulatory pathways associated with oncogenesis, in addition to the induction of oxidative stress, cell cycle arrest, upregulation of apoptotic genes, and inhibition of cell proliferation and angiogenesis in cancer cells. In this review, we discuss about the anticancer profile of luteolin.
AB - Therapeutic effect of phytochemicals has been emphasized in the traditional medicine owing to the presence of bioactive molecules, such as polyphenols. Luteolin is a flavone belonging to the flavonoid class of polyphenolic phytochemicals with healing effect on hypertension, inflammatory disorders, and cancer due to its action as pro-oxidants and antioxidants. The anticancer profile of luteolin is of interest due to the toxic effect of contemporary chemotherapy paradigm, leading to the pressing need for the development and identification of physiologically benevolent anticancer agents and molecules. Luteolin exerts anticancer activity by downregulation of key regulatory pathways associated with oncogenesis, in addition to the induction of oxidative stress, cell cycle arrest, upregulation of apoptotic genes, and inhibition of cell proliferation and angiogenesis in cancer cells. In this review, we discuss about the anticancer profile of luteolin.
UR - https://www.scopus.com/pages/publications/85143731852
U2 - 10.1186/s12935-022-02808-3
DO - 10.1186/s12935-022-02808-3
M3 - Artículo de revisión
AN - SCOPUS:85143731852
SN - 1475-2867
VL - 22
JO - Cancer Cell International
JF - Cancer Cell International
IS - 1
M1 - 386
ER -
