Evaluation of toxic effects of rabeprazole sodium on the plant-based eukaryotic test models

Muhammad Torequl Islam; Marcello Iriti; Hicham Harhar; Youssef Elouafy; Md Shimul Bhuia; Imane Chamkhi; Eda Sönmez Gürer; Javad Sharifi-Rad

doi:10.17533/udea.vitae.v31n2a352429

Evaluation of toxic effects of rabeprazole sodium on the plant-based eukaryotic test models

Muhammad Torequl Islam
, Marcello Iriti
, Hicham Harhar
, Youssef Elouafy
, Md Shimul Bhuia
, Imane Chamkhi
, Eda Sönmez Gürer
, Javad Sharifi-Rad

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Rabeprazole (RPZ), a widely used proton pump inhibitor, is known to have toxic effects on human beings. Objective: To evaluate the toxic effects of RPZ sodium (RPZ-Na) using plant-based eukaryotic test systems. Methods: The toxic effect of RPZ-Na (0.025-0.4 mM) was evaluated on Allium cepa, Allium sativum, and Cicer arietinum at different exposure times using CuSO₄ as a reference standard. Results: RPZ-Na concentration-dependently reduced the root length of A. cepa and A. sativum, as well as the shoot and root lengths of C. arietinum. RPZ-Na at 0.1 to 0.4 µg/mL and at 48 h exposure time exerted toxic effects on the tested systems. Conclusions: RPZ-Na exerted a concentration-and time-dependent toxic effect on A. cepa, A. sativum, and C. arietinum. Therefore, it is important to take adequate precautions during its long-term use.

Original language	English
Article number	352429
Journal	Vitae
Volume	31
Issue number	2
DOIs	https://doi.org/10.17533/udea.vitae.v31n2a352429
State	Published - 27 Sep 2024
Externally published	Yes

Keywords

Allium cepa
Allium sativum
Cicer arietinum
Rabeprazole sodium
Toxicity monitoring tools

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10.17533/udea.vitae.v31n2a352429

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title = "Evaluation of toxic effects of rabeprazole sodium on the plant-based eukaryotic test models",

abstract = "Background: Rabeprazole (RPZ), a widely used proton pump inhibitor, is known to have toxic effects on human beings. Objective: To evaluate the toxic effects of RPZ sodium (RPZ-Na) using plant-based eukaryotic test systems. Methods: The toxic effect of RPZ-Na (0.025-0.4 mM) was evaluated on Allium cepa, Allium sativum, and Cicer arietinum at different exposure times using CuSO4 as a reference standard. Results: RPZ-Na concentration-dependently reduced the root length of A. cepa and A. sativum, as well as the shoot and root lengths of C. arietinum. RPZ-Na at 0.1 to 0.4 µg/mL and at 48 h exposure time exerted toxic effects on the tested systems. Conclusions: RPZ-Na exerted a concentration-and time-dependent toxic effect on A. cepa, A. sativum, and C. arietinum. Therefore, it is important to take adequate precautions during its long-term use.",

keywords = "Allium cepa, Allium sativum, Cicer arietinum, Rabeprazole sodium, Toxicity monitoring tools",

author = "Islam, \{Muhammad Torequl\} and Marcello Iriti and Hicham Harhar and Youssef Elouafy and Bhuia, \{Md Shimul\} and Imane Chamkhi and G{\"u}rer, \{Eda S{\"o}nmez\} and Javad Sharifi-Rad",

year = "2024",

month = sep,

day = "27",

doi = "10.17533/udea.vitae.v31n2a352429",

language = "Ingl{\'e}s",

volume = "31",

journal = "Vitae",

issn = "0121-4004",

publisher = "Universidad de Antioquia",

number = "2",

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TY - JOUR

T1 - Evaluation of toxic effects of rabeprazole sodium on the plant-based eukaryotic test models

AU - Islam, Muhammad Torequl

AU - Iriti, Marcello

AU - Harhar, Hicham

AU - Elouafy, Youssef

AU - Bhuia, Md Shimul

AU - Chamkhi, Imane

AU - Gürer, Eda Sönmez

AU - Sharifi-Rad, Javad

PY - 2024/9/27

Y1 - 2024/9/27

N2 - Background: Rabeprazole (RPZ), a widely used proton pump inhibitor, is known to have toxic effects on human beings. Objective: To evaluate the toxic effects of RPZ sodium (RPZ-Na) using plant-based eukaryotic test systems. Methods: The toxic effect of RPZ-Na (0.025-0.4 mM) was evaluated on Allium cepa, Allium sativum, and Cicer arietinum at different exposure times using CuSO4 as a reference standard. Results: RPZ-Na concentration-dependently reduced the root length of A. cepa and A. sativum, as well as the shoot and root lengths of C. arietinum. RPZ-Na at 0.1 to 0.4 µg/mL and at 48 h exposure time exerted toxic effects on the tested systems. Conclusions: RPZ-Na exerted a concentration-and time-dependent toxic effect on A. cepa, A. sativum, and C. arietinum. Therefore, it is important to take adequate precautions during its long-term use.

AB - Background: Rabeprazole (RPZ), a widely used proton pump inhibitor, is known to have toxic effects on human beings. Objective: To evaluate the toxic effects of RPZ sodium (RPZ-Na) using plant-based eukaryotic test systems. Methods: The toxic effect of RPZ-Na (0.025-0.4 mM) was evaluated on Allium cepa, Allium sativum, and Cicer arietinum at different exposure times using CuSO4 as a reference standard. Results: RPZ-Na concentration-dependently reduced the root length of A. cepa and A. sativum, as well as the shoot and root lengths of C. arietinum. RPZ-Na at 0.1 to 0.4 µg/mL and at 48 h exposure time exerted toxic effects on the tested systems. Conclusions: RPZ-Na exerted a concentration-and time-dependent toxic effect on A. cepa, A. sativum, and C. arietinum. Therefore, it is important to take adequate precautions during its long-term use.

KW - Allium cepa

KW - Allium sativum

KW - Cicer arietinum

KW - Rabeprazole sodium

KW - Toxicity monitoring tools

UR - https://www.scopus.com/pages/publications/85205969838

U2 - 10.17533/udea.vitae.v31n2a352429

DO - 10.17533/udea.vitae.v31n2a352429

M3 - Artículo

AN - SCOPUS:85205969838

SN - 0121-4004

VL - 31

JO - Vitae

JF - Vitae

IS - 2

M1 - 352429

ER -

Evaluation of toxic effects of rabeprazole sodium on the plant-based eukaryotic test models

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