Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis

Bahare Salehi; Elena Maria Varoni; Mehdi Sharifi-Rad; Sadegh Rajabi; Paolo Zucca; Marcello Iriti; Javad Sharifi-Rad

doi:10.1016/j.phymed.2018.07.001

Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis

Bahare Salehi
, Elena Maria Varoni
, Mehdi Sharifi-Rad
, Sadegh Rajabi
, Paolo Zucca
, Marcello Iriti
, Javad Sharifi-Rad

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Background: The plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. Purpose: In this view, epithelial-mesenchymal transition (EMT) represents a novel and major target in anticancer therapy. Therefore, this narrative review aims to provide an updated overview on the bioactive phytochemicals with anti-EMT activity. Conclusion: Among the plant products reviewed, phenylpropanoids were the most investigated at preclinical phase, thus exhibiting a promising potential as anticancer drugs, though an evidence-based clinical efficacy is still lacking.

Original language	English
Pages (from-to)	125-136
Number of pages	12
Journal	Phytomedicine
Volume	55
DOIs	https://doi.org/10.1016/j.phymed.2018.07.001
State	Published - 1 Mar 2019
Externally published	Yes

Keywords

Alkaloids
Anticancer phytotherapeutics
Bioactive phytochemicals
Chemoprevention
Isoprenoids
Phenylpropanoids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phymed.2018.07.001

Cite this

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title = "Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis",

abstract = "Background: The plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. Purpose: In this view, epithelial-mesenchymal transition (EMT) represents a novel and major target in anticancer therapy. Therefore, this narrative review aims to provide an updated overview on the bioactive phytochemicals with anti-EMT activity. Conclusion: Among the plant products reviewed, phenylpropanoids were the most investigated at preclinical phase, thus exhibiting a promising potential as anticancer drugs, though an evidence-based clinical efficacy is still lacking.",

keywords = "Alkaloids, Anticancer phytotherapeutics, Bioactive phytochemicals, Chemoprevention, Isoprenoids, Phenylpropanoids",

author = "Bahare Salehi and Varoni, \{Elena Maria\} and Mehdi Sharifi-Rad and Sadegh Rajabi and Paolo Zucca and Marcello Iriti and Javad Sharifi-Rad",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier GmbH",

year = "2019",

month = mar,

day = "1",

doi = "10.1016/j.phymed.2018.07.001",

language = "Ingl{\'e}s",

volume = "55",

pages = "125--136",

journal = "Phytomedicine",

issn = "0944-7113",

publisher = "Elsevier GmbH",

}

TY - JOUR

T1 - Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis

AU - Salehi, Bahare

AU - Varoni, Elena Maria

AU - Sharifi-Rad, Mehdi

AU - Rajabi, Sadegh

AU - Zucca, Paolo

AU - Iriti, Marcello

AU - Sharifi-Rad, Javad

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: The plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. Purpose: In this view, epithelial-mesenchymal transition (EMT) represents a novel and major target in anticancer therapy. Therefore, this narrative review aims to provide an updated overview on the bioactive phytochemicals with anti-EMT activity. Conclusion: Among the plant products reviewed, phenylpropanoids were the most investigated at preclinical phase, thus exhibiting a promising potential as anticancer drugs, though an evidence-based clinical efficacy is still lacking.

AB - Background: The plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. Purpose: In this view, epithelial-mesenchymal transition (EMT) represents a novel and major target in anticancer therapy. Therefore, this narrative review aims to provide an updated overview on the bioactive phytochemicals with anti-EMT activity. Conclusion: Among the plant products reviewed, phenylpropanoids were the most investigated at preclinical phase, thus exhibiting a promising potential as anticancer drugs, though an evidence-based clinical efficacy is still lacking.

KW - Alkaloids

KW - Anticancer phytotherapeutics

KW - Bioactive phytochemicals

KW - Chemoprevention

KW - Isoprenoids

KW - Phenylpropanoids

UR - https://www.scopus.com/pages/publications/85056208140

U2 - 10.1016/j.phymed.2018.07.001

DO - 10.1016/j.phymed.2018.07.001

M3 - Artículo de revisión

C2 - 30668422

AN - SCOPUS:85056208140

SN - 0944-7113

VL - 55

SP - 125

EP - 136

JO - Phytomedicine

JF - Phytomedicine

ER -

Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis

Abstract

Keywords

UN SDGs

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