Curcumin’s nanomedicine formulations for therapeutic application in neurological diseases

Bahare Salehi; Daniela Calina; Anca Oana Docea; Niranjan Koirala; Sushant Aryal; Domenico Lombardo; Luigi Pasqua; Yasaman Taheri; Carla Marina Salgado Castillo; Miquel Martorell; Natália Martins; Marcello Iriti; Hafiz Ansar Rasul Suleria; Javad Sharifi‐rad

doi:10.3390/jcm9020430

Curcumin’s nanomedicine formulations for therapeutic application in neurological diseases

Bahare Salehi
, Daniela Calina
, Anca Oana Docea
, Niranjan Koirala
, Sushant Aryal
, Domenico Lombardo
, Luigi Pasqua
, Yasaman Taheri
, Carla Marina Salgado Castillo
, Miquel Martorell
, Natália Martins
, Marcello Iriti
, Hafiz Ansar Rasul Suleria
, Javad Sharifi‐rad

Research output: Contribution to journal › Review article › peer-review

163 Scopus citations

Abstract

The brain is the body’s control center, so when a disease affects it, the outcomes are devastating. Alzheimer’s and Parkinson’s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β‐binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, and synaptogenesis promotion. The therapeutic limitation of curcumin is its bioavailability, and to address this problem, new nanoformulations are being developed. The present review aims to summarize the general bioactivity of curcumin in neurological disorders, how functional molecules are extracted, and the different types of nanoformulations available.

Original language	English
Article number	430
Journal	Journal of Clinical Medicine
Volume	9
Issue number	2
DOIs	https://doi.org/10.3390/jcm9020430
State	Published - Feb 2020
Externally published	Yes

Keywords

Curcumin
Liposomes
Nanocarriers
Nanocurcumin
Neurological disorders

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Salehi, B., Calina, D., Docea, A. O., Koirala, N., Aryal, S., Lombardo, D., Pasqua, L., Taheri, Y., Castillo, C. M. S., Martorell, M., Martins, N., Iriti, M., Suleria, H. A. R., & Sharifi‐rad, J. (2020). Curcumin’s nanomedicine formulations for therapeutic application in neurological diseases. Journal of Clinical Medicine, 9(2), Article 430. https://doi.org/10.3390/jcm9020430

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abstract = "The brain is the body{\textquoteright}s control center, so when a disease affects it, the outcomes are devastating. Alzheimer{\textquoteright}s and Parkinson{\textquoteright}s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β‐binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, and synaptogenesis promotion. The therapeutic limitation of curcumin is its bioavailability, and to address this problem, new nanoformulations are being developed. The present review aims to summarize the general bioactivity of curcumin in neurological disorders, how functional molecules are extracted, and the different types of nanoformulations available.",

keywords = "Curcumin, Liposomes, Nanocarriers, Nanocurcumin, Neurological disorders",

author = "Bahare Salehi and Daniela Calina and Docea, \{Anca Oana\} and Niranjan Koirala and Sushant Aryal and Domenico Lombardo and Luigi Pasqua and Yasaman Taheri and Castillo, \{Carla Marina Salgado\} and Miquel Martorell and Nat{\'a}lia Martins and Marcello Iriti and Suleria, \{Hafiz Ansar Rasul\} and Javad Sharifi‐rad",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = feb,

doi = "10.3390/jcm9020430",

language = "Ingl{\'e}s",

volume = "9",

journal = "Journal of Clinical Medicine",

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TY - JOUR

T1 - Curcumin’s nanomedicine formulations for therapeutic application in neurological diseases

AU - Salehi, Bahare

AU - Calina, Daniela

AU - Docea, Anca Oana

AU - Koirala, Niranjan

AU - Aryal, Sushant

AU - Lombardo, Domenico

AU - Pasqua, Luigi

AU - Taheri, Yasaman

AU - Castillo, Carla Marina Salgado

AU - Martorell, Miquel

AU - Martins, Natália

AU - Iriti, Marcello

AU - Suleria, Hafiz Ansar Rasul

AU - Sharifi‐rad, Javad

PY - 2020/2

Y1 - 2020/2

N2 - The brain is the body’s control center, so when a disease affects it, the outcomes are devastating. Alzheimer’s and Parkinson’s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β‐binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, and synaptogenesis promotion. The therapeutic limitation of curcumin is its bioavailability, and to address this problem, new nanoformulations are being developed. The present review aims to summarize the general bioactivity of curcumin in neurological disorders, how functional molecules are extracted, and the different types of nanoformulations available.

AB - The brain is the body’s control center, so when a disease affects it, the outcomes are devastating. Alzheimer’s and Parkinson’s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β‐binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, and synaptogenesis promotion. The therapeutic limitation of curcumin is its bioavailability, and to address this problem, new nanoformulations are being developed. The present review aims to summarize the general bioactivity of curcumin in neurological disorders, how functional molecules are extracted, and the different types of nanoformulations available.

KW - Curcumin

KW - Liposomes

KW - Nanocarriers

KW - Nanocurcumin

KW - Neurological disorders

UR - https://www.scopus.com/pages/publications/85081649200

U2 - 10.3390/jcm9020430

DO - 10.3390/jcm9020430

M3 - Artículo de revisión

AN - SCOPUS:85081649200

SN - 2077-0383

VL - 9

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 2

M1 - 430

ER -

Curcumin’s nanomedicine formulations for therapeutic application in neurological diseases

Abstract

Keywords

UN SDGs

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